null

SMILES: N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1

InChI Key: InChIKey=DQQCXFUUJRYTMD-QGZVFWFLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259276 (US9499547, 17) Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1 |r| Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259276 (US9499547, 17) Show SMILES N[C@H](COc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccccc1 |r| Show InChI InChI=1S/C22H18N4O2/c23-17(15-6-2-1-3-7-15)14-27-22-11-10-21-24-13-18(26(21)25-22)20-12-16-8-4-5-9-19(16)28-20/h1-13,17H,14,23H2/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair