null

SMILES: NCC(Cc1ccccc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=HHFGLHGTSSJJFJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259285 (US9499547, 26) Show SMILES NCC(Cc1ccccc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:2.2| Show InChI InChI=1S/C23H20N4O2/c24-14-18(12-16-6-2-1-3-7-16)28-23-11-10-22-25-15-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13,15,18H,12,14,24H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259285 (US9499547, 26) Show SMILES NCC(Cc1ccccc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:2.2| Show InChI InChI=1S/C23H20N4O2/c24-14-18(12-16-6-2-1-3-7-16)28-23-11-10-22-25-15-19(27(22)26-23)21-13-17-8-4-5-9-20(17)29-21/h1-11,13,15,18H,12,14,24H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair