null

SMILES: COc1cccc2oc(cc12)-c1cnc2ccc(OCC(N)C3CC3)nn12

InChI Key: InChIKey=OLUBNFKIAWVZDO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259300   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259300 (US9499547, 41) Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCC(N)C3CC3)nn12 |w:20.22| Show InChI InChI=1S/C20H20N4O3/c1-25-16-3-2-4-17-13(16)9-18(27-17)15-10-22-19-7-8-20(23-24(15)19)26-11-14(21)12-5-6-12/h2-4,7-10,12,14H,5-6,11,21H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair
Glutathione S-transferase P/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] (Homo sapiens (Human))	BDBM259300 (US9499547, 41) Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(OCC(N)C3CC3)nn12 |w:20.22| Show InChI InChI=1S/C20H20N4O3/c1-25-16-3-2-4-17-13(16)9-18(27-17)15-10-22-19-7-8-20(23-24(15)19)26-11-14(21)12-5-6-12/h2-4,7-10,12,14H,5-6,11,21H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair