BDBM259313 US9499547, 54

SMILES: NCC(Cc1ccncc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=HSVIIWOGDKRPON-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 259313   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GST-MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) (Homo sapiens (Human))	BDBM259313 (US9499547, 54) Show SMILES NCC(Cc1ccncc1)Oc1ccc2ncc(-c3cc4ccccc4o3)n2n1 |w:2.2| Show InChI InChI=1S/C22H19N5O2/c23-13-17(11-15-7-9-24-10-8-15)28-22-6-5-21-25-14-18(27(21)26-22)20-12-16-3-1-2-4-19(16)29-20/h1-10,12,14,17H,11,13,23H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	7.5	22
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...				US Patent US9499547 (2016) BindingDB Entry DOI: 10.7270/Q2736PVK
					More data for this Ligand-Target Pair