null
SMILES: C\C=C(/C1CCNCC1)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
InChI Key: InChIKey=KVWSOQMUSXAHGJ-YAXRCOADSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM259356 (US9505745, 33 | US9790212, Example 33) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent | Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... | US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 (Homo sapiens (Human)) | BDBM259356 (US9505745, 33 | US9790212, Example 33) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Intellectual Property (No. 2) Limited US Patent | Assay Description Protocol 2: Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Hu... | US Patent US9505745 (2016) BindingDB Entry DOI: 10.7270/Q23B5Z3T | |||||||||||
More data for this Ligand-Target Pair |