BDBM259484 US9512126, 25

SMILES: Cc1cc(ccc1C(=O)NC1CC1)-c1cnc2c(NCCC(F)(F)F)cc(nn12)C1(CC1)c1cccc(F)c1

InChI Key: InChIKey=HDRMLGRMOIYWNB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 259484   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GST-Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM259484 (US9512126, 25) Show SMILES Cc1cc(ccc1C(=O)NC1CC1)-c1cnc2c(NCCC(F)(F)F)cc(nn12)C1(CC1)c1cccc(F)c1 Show InChI InChI=1S/C29H27F4N5O/c1-17-13-18(5-8-22(17)27(39)36-21-6-7-21)24-16-35-26-23(34-12-11-29(31,32)33)15-25(37-38(24)26)28(9-10-28)19-3-2-4-20(30)14-19/h2-5,8,13-16,21,34H,6-7,9-12H2,1H3,(H,36,39)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	7.7	22
Bayer Intellectual Property GmbH US Patent					Assay Description The human kinase Mps-1 phosphorylates a biotinylated substrate peptide. Detection of the phosphorylated product is achieved by time-resolved fluoresc...				US Patent US9512126 (2016) BindingDB Entry DOI: 10.7270/Q2Q23Z5S
					More data for this Ligand-Target Pair