null

SMILES: Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)cc1C#N

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259552   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 [1091-1325] (Homo sapiens (Human))	BDBM259552 (US9505749, 63) Show SMILES Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)cc1C#N |r,wU:6.5,wD:9.12,(8.67,-5.39,;7.34,-4.62,;7.34,-3.08,;6,-2.31,;4.67,-3.08,;3.33,-2.31,;3.33,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;4.67,,;3.33,3.85,;2,4.62,;2,6.16,;.67,3.85,;-.67,4.62,;-2,3.85,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-8.67,4.62,;-8.67,6.16,;-7.34,6.93,;-6,6.16,;-4.67,6.93,;-4.67,8.47,;-3.33,6.16,;4.67,-4.62,;6,-5.39,;6,-6.93,;6,-8.47,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.33	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...				US Patent US9505749 (2016) BindingDB Entry DOI: 10.7270/Q2FN154F
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM259552 (US9505749, 63) Show SMILES Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)cc1C#N |r,wU:6.5,wD:9.12,(8.67,-5.39,;7.34,-4.62,;7.34,-3.08,;6,-2.31,;4.67,-3.08,;3.33,-2.31,;3.33,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;4.67,,;3.33,3.85,;2,4.62,;2,6.16,;.67,3.85,;-.67,4.62,;-2,3.85,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-8.67,4.62,;-8.67,6.16,;-7.34,6.93,;-6,6.16,;-4.67,6.93,;-4.67,8.47,;-3.33,6.16,;4.67,-4.62,;6,-5.39,;6,-6.93,;6,-8.47,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	802	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...				US Patent US9505749 (2016) BindingDB Entry DOI: 10.7270/Q2FN154F
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM259552 (US9505749, 63) Show SMILES Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)cc1C#N |r,wU:6.5,wD:9.12,(8.67,-5.39,;7.34,-4.62,;7.34,-3.08,;6,-2.31,;4.67,-3.08,;3.33,-2.31,;3.33,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;4.67,,;3.33,3.85,;2,4.62,;2,6.16,;.67,3.85,;-.67,4.62,;-2,3.85,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-8.67,4.62,;-8.67,6.16,;-7.34,6.93,;-6,6.16,;-4.67,6.93,;-4.67,8.47,;-3.33,6.16,;4.67,-4.62,;6,-5.39,;6,-6.93,;6,-8.47,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	586	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description PARP1 biochemical assay was purchased as a kit from Trevigen (cat.#4676-096-K) and used per manufacturers recommendations.PARP2 biochemical assay was...				US Patent US9505749 (2016) BindingDB Entry DOI: 10.7270/Q2FN154F
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 [946-1162] (Homo sapiens (Human))	BDBM259552 (US9505749, 63) Show SMILES Clc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)CCCc2nc3ccccc3c(=O)[nH]2)cc1C#N |r,wU:6.5,wD:9.12,(8.67,-5.39,;7.34,-4.62,;7.34,-3.08,;6,-2.31,;4.67,-3.08,;3.33,-2.31,;3.33,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;4.67,,;3.33,3.85,;2,4.62,;2,6.16,;.67,3.85,;-.67,4.62,;-2,3.85,;-3.33,4.62,;-4.67,3.85,;-6,4.62,;-7.34,3.85,;-8.67,4.62,;-8.67,6.16,;-7.34,6.93,;-6,6.16,;-4.67,6.93,;-4.67,8.47,;-3.33,6.16,;4.67,-4.62,;6,-5.39,;6,-6.93,;6,-8.47,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.653	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The tankyrase 1 biochemical activity of the compounds was assayed in the following assay buffer (50 mM MOPS pH7.5, 100 mM NaCl, 2.5 mM MgCl2, 0.01% T...				US Patent US9505749 (2016) BindingDB Entry DOI: 10.7270/Q2FN154F
					More data for this Ligand-Target Pair