BDBM2597 (Arylindolyl)maleimide deriv. 19::3-(1-methyl-1H-indol-3-yl)-4-(naphthalen-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::ROCHE screening, 60

SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12

InChI Key: InChIKey=STTILKKNKXMNIF-UHFFFAOYSA-N

Data: 3 IC50

PDB links: 7 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 2597   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Kinase C (Rattus norvegicus (rat))	BDBM2597 ((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...) Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	7.5	30
Roche Products Limited					Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM2597 ((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...) Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technical University of Dortmund					Assay Description IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...				ACS Chem Biol 10: 289-98 (2015) Article DOI: 10.1021/cb500908d BindingDB Entry DOI: 10.7270/Q2WH2NRB
					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM2597 ((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...) Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12 |t:4| Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.5	37
Roche Products Limited					Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair