null
SMILES: CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N
InChI Key: InChIKey=JGIBKTCCYJBOMS-VGOFMYFVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ribosomal protein S6 kinase alpha-3 [399-740] (Homo sapiens (Human)) | BDBM259837 (US9505766, 41) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | 8.0 | 22 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM259837 (US9505766, 41) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 650 | n/a | n/a | n/a | n/a | 7.6 | 25 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Nek2 [T175A] (Homo sapiens (Human)) | BDBM259837 (US9505766, 41) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | 7.6 | 25 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description For RSK2 kinase assays, see Example 64 above. Full-length human T175A NEK2 (referred to as NEK2) was expressed and purified as previously described (... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair |