BDBM260155 US9522910, Table 1 Compound 5: 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-(2-{[1,2,4]triazolo[4,3-b]pyridazin-3-yl}ethynyl)benzamide
SMILES: CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nnc4cccnn34)cc2C(F)(F)F)CC1
InChI Key: InChIKey=KWRIGWZQRBNVJT-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase ABL1 [T315I] (Homo sapiens (Human)) | BDBM260155 (US9522910, Table 1 Compound 5: 4-methyl-N-{4-[(4-m...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 (Homo sapiens (Human)) | BDBM260155 (US9522910, Table 1 Compound 5: 4-methyl-N-{4-[(4-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair |