BDBM26046 (1E)-5-[2-(morpholin-4-ylmethyl)-5-(pyridin-4-yl)-1H-imidazol-4-yl]-2,3-dihydro-1H-indene-1-hydroxylamine::imidazole-based compound, 7

SMILES: O=NC1CCc2cc(ccc12)-c1[nH]c(CN2CCOCC2)nc1-c1ccncc1

InChI Key: InChIKey=VMHUMZQLFVVMEX-UHFFFAOYSA-N

Data: 1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM26046 ((1E)-5-[2-(morpholin-4-ylmethyl)-5-(pyridin-4-yl)-...) Show SMILES O=NC1CCc2cc(ccc12)-c1[nH]c(CN2CCOCC2)nc1-c1ccncc1 Show InChI InChI=1S/C22H23N5O2/c28-26-19-4-2-16-13-17(1-3-18(16)19)22-21(15-5-7-23-8-6-15)24-20(25-22)14-27-9-11-29-12-10-27/h1,3,5-8,13,19H,2,4,9-12,14H2,(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	15.8	n/a	n/a	n/a	7.5	22
GSK					Assay Description The kinase enzyme, fluorescent ligand and a variable concentration of test compound are incubated together to reach thermodynamic equilibrium under c...				Bioorg Med Chem Lett 18: 4373-6 (2008) Article DOI: 10.1016/j.bmcl.2008.06.070 BindingDB Entry DOI: 10.7270/Q26D5R86
					More data for this Ligand-Target Pair