BDBM260659 US9533985, 47
SMILES: CN(C)c1ccc2n(C)c(=O)n(-c3ccc(C[C@H](NC(=O)c4c(F)cc(NS(=O)(=O)c5ccc(cc5)-n5cncn5)cc4F)C(O)=O)cc3)c(=O)c2c1
InChI Key: InChIKey=VMDLUIBMPQVKHH-LJAQVGFWSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin (Mus musculus (Mouse)-Homo sapiens (Human)) | BDBM260659 (US9533985, 47) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | 9.6 | 4 |
EA Pharma Co., Ltd. US Patent | Assay Description The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA... | US Patent US9533985 (2017) BindingDB Entry DOI: 10.7270/Q20C4TQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mucosal addressin cell adhesion molecule 1 (MAdCAM-1)/Alpha-4 Beta-7 Integrin (Mus musculus (Mouse)-Homo sapiens (Human)) | BDBM260659 (US9533985, 47) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 9.6 | 4 |
EA Pharma Co., Ltd. US Patent | Assay Description The ability of test substances to inhibit the binding of a human B cell line, RPMI-8866, which is known to express α4β7 integrin, to MAdCA... | US Patent US9533985 (2017) BindingDB Entry DOI: 10.7270/Q20C4TQ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular cell adhesion protein 1 (VCAM-1)/Alpha-4 Beta-1 Integrin (Homo sapiens (Human)) | BDBM260659 (US9533985, 47) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 340 | n/a | n/a | n/a | n/a | 9.6 | 4 |
EA Pharma Co., Ltd. US Patent | Assay Description The ability of test substances to inhibit the binding of a human T-cell line, Jurkat, which is known to express α4β1 integrin, to VCAM-1 w... | US Patent US9533985 (2017) BindingDB Entry DOI: 10.7270/Q20C4TQ8 | |||||||||||
More data for this Ligand-Target Pair |