BDBM261161 2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-methoxy-6-methylphenyl}pyridin-2-yl)amino]ethanol::US10092570, Example 184::US9707233, 184::US9730939, Example 184

SMILES: COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N

InChI Key: InChIKey=XWTYCMXAMJANPC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 261161   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110delta/p85alpha (Homo sapiens (Human))	BDBM261161 (2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261161 (2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261161 (2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)Nc1ncnc(N)c1C(C)=N Show InChI InChI=1S/C23H28ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)25)22(26)29-11-30-23)21(33-4)19(12)15-5-6-18(28-10-15)27-7-8-32/h5-6,9-11,14,25,32H,7-8H2,1-4H3,(H,27,28)(H3,26,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5
					More data for this Ligand-Target Pair