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BDBM26134 (4-nonylphenyl)boranediol::Phenylboronic Acid, 13

SMILES: CCCCCCCCCc1ccc(cc1)B(O)O

InChI Key: InChIKey=VONVJOGSLHAKOX-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26134   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
PDB
MMDB

KEGG

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Article
PubMed
n/an/a 9.10n/an/an/an/a7.437



University of Oxford



Assay Description
[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...


J Med Chem 51: 7057-60 (2008)

More data for this
Ligand-Target Pair
Monoglyceride Lipase (MGL)


(Homo sapiens (human))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
PDB
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PubMed
n/an/a 7.90E+3n/an/an/an/an/an/a



University of Oxford



Assay Description
The endpoint enzymatic assay was developed to quantify human recombinant MGL activity with 2-AG. The formation of arachidonic acid and depletion of ...


J Med Chem 51: 7057-60 (2008)

More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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PubMed
n/an/a 2.92E+3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting method


Citation and Details
More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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PubMed
n/an/a 100n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substr...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Endothelial lipase (EL)


(Homo sapiens (Human))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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PubMed
n/an/a 1.00E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human endothelial lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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PubMed
n/an/a 4.20E+4n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens)
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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Article
PubMed
n/an/a 1.40E+3n/an/an/an/an/an/a



Tufts University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate...


Bioorg Med Chem Lett 22: 1397-401 (2012)

More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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PubMed
n/an/a 9.10E+3n/an/an/an/an/an/a



Sapienza Universit£ di Roma

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...


Citation and Details
More data for this
Ligand-Target Pair