BindingDB PrimarySearch

BDBM26144 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate::2-Arachidonoylmonoglycerol (2-AG)::2-arachidonoylglycerol (2-AG)::2-arachidonyl-glycerol::CHEMBL122972

SMILES: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC(CO)CO

InChI Key: InChIKey=RCRCTBLIHCHWDZ-DOFZRALJSA-N

Data: 14 KI 3 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 26144
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Liver fatty acid binding protein (FABP1) (Mus musculus (Mouse))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Avanti Polar Lipids					Assay Description The following fluorescent ligand displacement assays at 24 �C were used to further confirm and/or determine if the cytosolic lipidic ligand "chaperon...				Biochemistry 55: 5243-55 (2016) Article DOI: 10.1021/acs.biochem.6b00446 BindingDB Entry DOI: 10.7270/Q2MS3RJJ
Avanti Polar Lipids					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Utrecht University Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF				J Med Chem 45: 3709-20 (2002) BindingDB Entry DOI: 10.7270/Q2WD3ZXN
Utrecht University Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Utrecht University Curated by ChEMBL					Assay Description Displacement of [3H]-CP-55,940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF				J Med Chem 45: 3709-20 (2002) BindingDB Entry DOI: 10.7270/Q2WD3ZXN
Utrecht University Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells				J Med Chem 54: 8278-88 (2011) Article DOI: 10.1021/jm200529h BindingDB Entry DOI: 10.7270/Q23J3DC3
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	472	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to rat CB1 receptor				Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	472	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Sassari Curated by ChEMBL					Assay Description Binding affinity to CB1 receptor (unknown origin)				Bioorg Med Chem 24: 5291-5301 (2016) Article DOI: 10.1016/j.bmc.2016.08.055
Universit£ degli Studi di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	472	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Sassari Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assay				Eur J Med Chem 112: 66-80 (2016) BindingDB Entry DOI: 10.7270/Q24B336C
Universit£ degli Studi di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense de Madrid Curated by ChEMBL					Assay Description Displacement of [3H]-CP55940 from human CB1 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting				J Med Chem 54: 5265-9 (2011) Article DOI: 10.1021/jm2004392 BindingDB Entry DOI: 10.7270/Q25D8S6J
Universidad Complutense de Madrid Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille Curated by ChEMBL					Assay Description Binding affinity to CB1R (unknown origin)				J Med Chem 60: 4-46 (2017) Article DOI: 10.1021/acs.jmedchem.6b00538 BindingDB Entry DOI: 10.7270/Q2348NZC
Universit£ de Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad Complutense de Madrid Curated by ChEMBL					Assay Description Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting				J Med Chem 54: 5265-9 (2011) Article DOI: 10.1021/jm2004392 BindingDB Entry DOI: 10.7270/Q25D8S6J
Universidad Complutense de Madrid Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Sassari Curated by ChEMBL					Assay Description Binding affinity to CB2 receptor (unknown origin)				Bioorg Med Chem 24: 5291-5301 (2016) Article DOI: 10.1016/j.bmc.2016.08.055
Universit£ degli Studi di Sassari Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Binding affinity to human CB2 receptor				Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Displacement of [3H]CP55940 from human CB2 receptor expressed in human HEK293 cells				J Med Chem 54: 8278-88 (2011) Article DOI: 10.1021/jm200529h BindingDB Entry DOI: 10.7270/Q23J3DC3
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Utrecht University Curated by ChEMBL					Assay Description Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]-AEA as substrate in the 0-25 uM conc				J Med Chem 45: 3709-20 (2002) BindingDB Entry DOI: 10.7270/Q2WD3ZXN
Utrecht University Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Teikyo University Curated by ChEMBL					Assay Description Agonist activity at CB1 receptor expressed in NG108-15 cells assessed as increase in intracellular free calcium concentrations				Bioorg Med Chem 15: 854-67 (2006) Article DOI: 10.1016/j.bmc.2006.10.049 BindingDB Entry DOI: 10.7270/Q2ZK5G9W
Teikyo University Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a
Teikyo University Curated by ChEMBL					Assay Description Agonist activity at CB2 receptor expressed in HL60 cells assessed as increase in intracellular free calcium concentrations				Bioorg Med Chem 15: 854-67 (2006) Article DOI: 10.1016/j.bmc.2006.10.049 BindingDB Entry DOI: 10.7270/Q2ZK5G9W
Teikyo University Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor (Rattus norvegicus (rat))	BDBM26144 (1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Potency at CB1 receptor in rat brain by [35S]GTP-gamma-S binding assay				Bioorg Med Chem Lett 16: 2437-40 (2006) Article DOI: 10.1016/j.bmcl.2006.01.101 BindingDB Entry DOI: 10.7270/Q2MP561X
University of Kuopio Curated by ChEMBL					More data for this Ligand-Target Pair