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BDBM26149 2,4-dianilino pyrimidine, 6::3-({4-[(2-bromo-5-hydroxyphenyl)amino]pyrimidin-2-yl}amino)benzamide

SMILES: NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1

InChI Key: InChIKey=RQCALQIWVOZDDF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26149   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26149
PNG
(2,4-dianilino pyrimidine, 6 | 3-({4-[(2-bromo-5-hy...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1
Show InChI InChI=1S/C17H14BrN5O2/c18-13-5-4-12(24)9-14(13)22-15-6-7-20-17(23-15)21-11-3-1-2-10(8-11)16(19)25/h1-9,24H,(H2,19,25)(H2,20,21,22,23)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 41n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair