BDBM26149 2,4-dianilino pyrimidine, 6::3-({4-[(2-bromo-5-hydroxyphenyl)amino]pyrimidin-2-yl}amino)benzamide

SMILES: NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1

InChI Key: InChIKey=RQCALQIWVOZDDF-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lck (Mus musculus)	BDBM26149 (2,4-dianilino pyrimidine, 6 | 3-({4-[(2-bromo-5-hy...) Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1 Show InChI InChI=1S/C17H14BrN5O2/c18-13-5-4-12(24)9-14(13)22-15-6-7-20-17(23-15)21-11-3-1-2-10(8-11)16(19)25/h1-9,24H,(H2,19,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair