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BDBM26153 2,4-dianilino pyrimidine, 10::3-({4-[(2-hydroxy-6-methylphenyl)amino]pyrimidin-2-yl}amino)benzamide

SMILES: Cc1cccc(O)c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1

InChI Key: InChIKey=JUDHVHACWPERTL-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26153   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26153
PNG
(2,4-dianilino pyrimidine, 10 | 3-({4-[(2-hydroxy-6...)
Show SMILES Cc1cccc(O)c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-4-2-7-14(24)16(11)22-15-8-9-20-18(23-15)21-13-6-3-5-12(10-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)

More data for this
Ligand-Target Pair