BDBM26158 2,4-dianilino pyrimidine, 15::3-({2-[(3-carbamoylphenyl)amino]pyrimidin-4-yl}amino)-4-methylbenzamide

SMILES: Cc1ccc(cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1)C(N)=O

InChI Key: InChIKey=RJFKMWMYHHXZDG-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lck (Mus musculus)	BDBM26158 (2,4-dianilino pyrimidine, 15 | 3-({2-[(3-carbamoyl...) Show SMILES Cc1ccc(cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1)C(N)=O Show InChI InChI=1S/C19H18N6O2/c1-11-5-6-13(18(21)27)10-15(11)24-16-7-8-22-19(25-16)23-14-4-2-3-12(9-14)17(20)26/h2-10H,1H3,(H2,20,26)(H2,21,27)(H2,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair