BDBM261651 5-(4-(4-methylpiperazine-1-carbonyl)phenyl)-N-(4-(3-(3-((triisopropylsilyl)oxy)prop-1-yn-1-yl)phenyl)thiazol-2-yl)furan-2-carboxamide::US9708279, 28

SMILES: CC(C)[Si](OCC#Cc1cccc(c1)-c1csc(NC(=O)c2ccc(o2)-c2ccc(cc2)C(=O)N2CCN(C)CC2)n1)(C(C)C)C(C)C

InChI Key: InChIKey=YYCJRSKUCRYDDJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261651   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (L1196M) (Homo sapiens (Human))	BDBM261651 (5-(4-(4-methylpiperazine-1-carbonyl)phenyl)-N-(4-(...) Show SMILES CC(C)[Si](OCC#Cc1cccc(c1)-c1csc(NC(=O)c2ccc(o2)-c2ccc(cc2)C(=O)N2CCN(C)CC2)n1)(C(C)C)C(C)C Show InChI InChI=1S/C38H46N4O4SSi/c1-26(2)48(27(3)4,28(5)6)45-23-9-11-29-10-8-12-32(24-29)33-25-47-38(39-33)40-36(43)35-18-17-34(46-35)30-13-15-31(16-14-30)37(44)42-21-19-41(7)20-22-42/h8,10,12-18,24-28H,19-23H2,1-7H3,(H,39,40,43)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55.6	n/a	n/a	n/a	n/a	7.5	25
UNIVERSITÁ DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITÈ DE GENÈVE; UNIVERSITÈ CLAUDE BERNARD LYON 1 US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9708279 (2017) BindingDB Entry DOI: 10.7270/Q2MC921P
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM261651 (5-(4-(4-methylpiperazine-1-carbonyl)phenyl)-N-(4-(...) Show SMILES CC(C)[Si](OCC#Cc1cccc(c1)-c1csc(NC(=O)c2ccc(o2)-c2ccc(cc2)C(=O)N2CCN(C)CC2)n1)(C(C)C)C(C)C Show InChI InChI=1S/C38H46N4O4SSi/c1-26(2)48(27(3)4,28(5)6)45-23-9-11-29-10-8-12-32(24-29)33-25-47-38(39-33)40-36(43)35-18-17-34(46-35)30-13-15-31(16-14-30)37(44)42-21-19-41(7)20-22-42/h8,10,12-18,24-28H,19-23H2,1-7H3,(H,39,40,43)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.13E+3	n/a	n/a	n/a	n/a	7.5	25
UNIVERSITÁ DEGLI STUDI DI MILANO—BICOCCA; UNIVERSITÈ DE GENÈVE; UNIVERSITÈ CLAUDE BERNARD LYON 1 US Patent					Assay Description GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...				US Patent US9708279 (2017) BindingDB Entry DOI: 10.7270/Q2MC921P
					More data for this Ligand-Target Pair