BDBM261728 1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- yl)benzyl)-N- ((3RS,4SR)-3- hydroxytetrahydro- 2H-pyran-4-yl)-2- naphthamide::US9708302, 14
SMILES: Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@H]3CCOC[C@@H]3O)c(F)c3ccccc23)c(F)c1
InChI Key: InChIKey=GFRKKRCGBSUEOH-DQEYMECFSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M1 (RAT) | BDBM261728 (1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- y...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
HOFFMANN-LA-ROCHE INC. US Patent | Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin... | US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM261728 (1-fluoro-4-(2-fluoro- 4-(1-methyl-1H- pyrazol-4- y...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
HOFFMANN-LA-ROCHE INC. US Patent | Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin... | US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP | |||||||||||
More data for this Ligand-Target Pair |