BDBM261733 1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-yl]-4- [[6-(1-methylpyrazol- 4-yl)-3-pyridyl]methyl]- naphthalene-2- carboxamide::US9708302, 19
SMILES: Cn1cc(cn1)-c1ccc(Cc2cc(C(=O)N[C@@H]3CCOC[C@H]3O)c(F)c3ccccc23)cn1
InChI Key: InChIKey=PQZBCCGOIMNBLV-DNQXCXABSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M1 (RAT) | BDBM261733 (1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 97 | n/a | n/a | n/a | n/a |
HOFFMANN-LA-ROCHE INC. US Patent | Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin... | US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM261733 (1-fluoro-N-[(3S,4R)- 3-hydroxytetra- hydropyran-4-...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
HOFFMANN-LA-ROCHE INC. US Patent | Assay Description The assay is designed to select compounds that possess modulator activity at the acetylcholine muscarinic receptor expressed in CHO cells by measurin... | US Patent US9708302 (2017) BindingDB Entry DOI: 10.7270/Q2BV7JMP | |||||||||||
More data for this Ligand-Target Pair |