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BDBM26179 2,4-dianilino pyrimidine, 36::3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}benzamide::GTC000110A

SMILES: NC(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1

InChI Key: InChIKey=NQHLFCVNEBJHOT-UHFFFAOYSA-N

Data: 2 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26179   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
SYK Kinase


(Homo sapiens (Human))
BDBM26179
PNG
(2,4-dianilino pyrimidine, 36 | 3-{[4-(1H-indazol-4...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Show InChI InChI=1S/C18H15N7O/c19-17(26)11-3-1-4-12(9-11)22-18-20-8-7-16(24-18)23-14-5-2-6-15-13(14)10-21-25-15/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
D3R
n/an/a 533n/an/an/an/an/an/a



D3R



Assay Description
SYK assay_HTRF


D3R 225: (2015)


BindingDB Entry DOI: 10.7270/Q2CV4GM1
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26179
PNG
(2,4-dianilino pyrimidine, 36 | 3-{[4-(1H-indazol-4...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Show InChI InChI=1S/C18H15N7O/c19-17(26)11-3-1-4-12(9-11)22-18-20-8-7-16(24-18)23-14-5-2-6-15-13(14)10-21-25-15/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair