BDBM26184 2,4-dianilino pyrimidine, 41::3-({4-[(1,5-dimethyl-1H-indazol-4-yl)amino]pyrimidin-2-yl}amino)benzamide

SMILES: Cc1ccc2n(C)ncc2c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1

InChI Key: InChIKey=ZLWQZVBUIQXGBB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26184   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase LCK (Mus musculus)	BDBM26184 (2,4-dianilino pyrimidine, 41 | 3-({4-[(1,5-dimethy...) Show SMILES Cc1ccc2n(C)ncc2c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1 Show InChI InChI=1S/C20H19N7O/c1-12-6-7-16-15(11-23-27(16)2)18(12)25-17-8-9-22-20(26-17)24-14-5-3-4-13(10-14)19(21)28/h3-11H,1-2H3,(H2,21,28)(H2,22,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...				Bioorg Med Chem Lett 17: 4363-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.029 BindingDB Entry DOI: 10.7270/Q21R6NTD
					More data for this Ligand-Target Pair