BDBM2621 3-(6-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolylmaleimide deriv. 43::ROCHE screening, 45

SMILES: COc1ccc2c(cn(C)c2c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12

InChI Key: InChIKey=JSVMZIMMLIKDPH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human))	BDBM2621 (3-(6-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1...) Show SMILES COc1ccc2c(cn(C)c2c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12 |t:14| Show InChI InChI=1S/C23H19N3O3/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-10-13(29-3)8-9-15(17)19/h4-12H,1-3H3,(H,24,27,28)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technical University of Dortmund					Assay Description IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...				ACS Chem Biol 10: 289-98 (2015) Article DOI: 10.1021/cb500908d BindingDB Entry DOI: 10.7270/Q2WH2NRB
					More data for this Ligand-Target Pair
Protein Kinase C (Rattus norvegicus (rat))	BDBM2621 (3-(6-methoxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1...) Show SMILES COc1ccc2c(cn(C)c2c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12 |t:14| Show InChI InChI=1S/C23H19N3O3/c1-25-11-16(14-6-4-5-7-18(14)25)20-21(23(28)24-22(20)27)17-12-26(2)19-10-13(29-3)8-9-15(17)19/h4-12H,1-3H3,(H,24,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Products Limited					Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair