BDBM2623 1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-6-carboxylic acid::Bisindolylmaleimide deriv. 45::ROCHE screening, 44
SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3cc(ccc23)C(O)=O)c2ccccc12
InChI Key: InChIKey=BQVYRVFEBOGTBZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein cereblon/Serine/threonine-protein kinase TBK1 (Homo sapiens (Human)) | BDBM2623 (1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 971 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s... | ACS Chem Biol 10: 289-98 (2015) Article DOI: 10.1021/cb500908d BindingDB Entry DOI: 10.7270/Q2WH2NRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Kinase C (Rattus norvegicus (rat)) | BDBM2623 (1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Products Limited | Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his... | J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V | |||||||||||
More data for this Ligand-Target Pair |