BindingDB PrimarySearch

null

SMILES: CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21

InChI Key: InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 90 hits for monomerid = 26263
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit alpha-1 [G157C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.190	-13.3	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Heidelberg Curated by ChEMBL					Assay Description Binding affinity for rat GABA-A receptor alpha-1-beta-2-gamma-2 subunits expressed in HEK293 cells				J Med Chem 37: 4576-80 (1995) BindingDB Entry DOI: 10.7270/Q2154HPB
Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-A receptor; alpha-5/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2 (Rattus norvegicus (Rat)-RAT)	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Heidelberg Curated by ChEMBL					Assay Description Binding affinity for rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cells				J Med Chem 37: 4576-80 (1995) BindingDB Entry DOI: 10.7270/Q2154HPB
Heidelberg Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GABBA alpha5 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00793 BindingDB Entry DOI: 10.7270/Q2SX6J1D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	0.720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GABBA alpha2 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00793 BindingDB Entry DOI: 10.7270/Q2SX6J1D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	0.794	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GABBA alpha1 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00793 BindingDB Entry DOI: 10.7270/Q2SX6J1D
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity against alpha1-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP K_i Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
Synthélabo Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tokyo Dental College Curated by PDSP K_i Database									Biochem Pharmacol 55: 209-14 (1998) Article DOI: 10.1016/s0006-2952(97)00433-4 BindingDB Entry DOI: 10.7270/Q2NP22ZJ
Tokyo Dental College Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-A receptor; alpha-2/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity of the compound tested against alpha2-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
GABA-A receptor; alpha-2/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to GABBA alpha3 (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jnatprod.0c00793 BindingDB Entry DOI: 10.7270/Q2SX6J1D
TBA					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity against alpha3-beta3-gamma2 GABAA/BzR receptor subtype.				J Med Chem 41: 4130-42 (1998) Article DOI: 10.1021/jm980317y BindingDB Entry DOI: 10.7270/Q2W37VFJ
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wisconsin-Milwaukee Curated by ChEMBL					Assay Description Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2				J Med Chem 43: 71-95 (2000) BindingDB Entry DOI: 10.7270/Q2W37X0J
University of Wisconsin-Milwaukee Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universität Heidelberg Curated by PDSP K_i Database									Science 245: 1389-92 (1989) Article DOI: 10.1126/science.2551039 BindingDB Entry DOI: 10.7270/Q2C53JCF
Universität Heidelberg Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.39	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP K_i Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
Synthélabo Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [V202C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	-12.0	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP K_i Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
Synthélabo Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP K_i Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
Synthélabo Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5 (RAT)	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synthélabo Curated by PDSP K_i Database									J Biol Chem 274: 13370-4 (1999) Article DOI: 10.1074/jbc.274.19.13370 BindingDB Entry DOI: 10.7270/Q2765CWZ
Synthélabo Curated by PDSP K_i Database					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2	-11.7	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 1 (Rattus norvegicus (Rat))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Curated by PDSP K_i Database									J Pharmacol Exp Ther 256: 1154-60 (1991) BindingDB Entry DOI: 10.7270/Q2125R4D
Georgetown University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1 [T206C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.10	-11.8	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [T162C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	2.20	-11.8	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Clinic for Psychiatry Curated by PDSP K_i Database									Eur J Pharmacol 304: 155-62 (1996) Article DOI: 10.1016/0014-2999(96)00088-x BindingDB Entry DOI: 10.7270/Q2HD7T6P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [G200C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,D95C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.10	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.30	-11.4	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R224C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.30	-11.6	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R183C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.70	-11.5	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,L179C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	3.80	-11.5	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [A160C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,R233C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	4.10	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [V211C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4.10	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,T165C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	4.40	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [28-456]/beta-2 [26-512]/gamma-2 [40-467,T120C] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	4.40	-11.4	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2 [29-451]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	5.70	-11.1	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [S205C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	6.5	-11.2	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-3 [29-492]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	8.10	-10.9	n/a	n/a	n/a	n/a	n/a	7.4	22
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1 [S204C]/beta-2 [26-512]/gamma-2 [40-467] (Homo sapiens (Human))	BDBM26263 (Anexate \| CHEMBL407 \| FLUMAZENIL \| Ro15-1788 \| Rom...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	8.80	-11.0	n/a	n/a	n/a	n/a	n/a	n/a	25
University of Wisconsin at Madison					Assay Description Membrane homogenates were incubated at room temperature with a sub-Kd concentration of radioligand in the absence or presence of seven different conc...				J Med Chem 51: 7243-52 (2008) Article DOI: 10.1021/jm800889m BindingDB Entry DOI: 10.7270/Q2R78CJM
University of Wisconsin at Madison					More data for this Ligand-Target Pair				3D Structure (crystal)

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