null

SMILES: NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metallo-beta-lactamase type 2 (Serratia marcescens)	BDBM262650 (3-(cis 4-(guanidinomethyl)cyclohexyl)-2-(1H-tetraz...) Show SMILES NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F |r,wU:5.4,(-6.75,-11.21,;-6.35,-9.72,;-7.44,-8.64,;-4.86,-9.33,;-4.46,-7.84,;-2.98,-7.44,;-2.58,-5.95,;-1.09,-5.55,;,-6.64,;-.4,-8.13,;-1.89,-8.53,;1.49,-6.24,;2.58,-7.33,;4.06,-6.93,;4.52,-5.43,;3.37,-4.36,;1.89,-4.76,;.8,-3.67,;-.74,-3.67,;-1.22,-2.2,;.03,-1.3,;1.27,-2.2,;3.77,-2.87,;5.11,-2.1,;3.77,-1.33,;5.11,-3.64,;6,-5.03,;7.49,-4.64,;6.4,-6.52,;6.08,-3.5,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.19	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair
VIM-1 metallo-beta-lactamase (Klebsiella pneumoniae)	BDBM262650 (3-(cis 4-(guanidinomethyl)cyclohexyl)-2-(1H-tetraz...) Show SMILES NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F |r,wU:5.4,(-6.75,-11.21,;-6.35,-9.72,;-7.44,-8.64,;-4.86,-9.33,;-4.46,-7.84,;-2.98,-7.44,;-2.58,-5.95,;-1.09,-5.55,;,-6.64,;-.4,-8.13,;-1.89,-8.53,;1.49,-6.24,;2.58,-7.33,;4.06,-6.93,;4.52,-5.43,;3.37,-4.36,;1.89,-4.76,;.8,-3.67,;-.74,-3.67,;-1.22,-2.2,;.03,-1.3,;1.27,-2.2,;3.77,-2.87,;5.11,-2.1,;3.77,-1.33,;5.11,-3.64,;6,-5.03,;7.49,-4.64,;6.4,-6.52,;6.08,-3.5,)| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.44	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair
Metallo-beta-lactamase type 2 (Klebsiella pneumoniae)	BDBM262650 (3-(cis 4-(guanidinomethyl)cyclohexyl)-2-(1H-tetraz...) Show SMILES NC(=N)NC[C@H]1CCC(CC1)c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)C(F)(F)F |r,wU:5.4,(-6.75,-11.21,;-6.35,-9.72,;-7.44,-8.64,;-4.86,-9.33,;-4.46,-7.84,;-2.98,-7.44,;-2.58,-5.95,;-1.09,-5.55,;,-6.64,;-.4,-8.13,;-1.89,-8.53,;1.49,-6.24,;2.58,-7.33,;4.06,-6.93,;4.52,-5.43,;3.37,-4.36,;1.89,-4.76,;.8,-3.67,;-.74,-3.67,;-1.22,-2.2,;.03,-1.3,;1.27,-2.2,;3.77,-2.87,;5.11,-2.1,;3.77,-1.33,;5.11,-3.64,;6,-5.03,;7.49,-4.64,;6.4,-6.52,;6.08,-3.5,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.520	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair