BDBM262887 4'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)-4- (trifluoromethyl)biphenyl-3- sulfonamide::US9708336, 740
SMILES: NS(=O)(=O)c1c(ccc(-c2ccc(cc2)N2CCC(O)CC2)c1-c1nnn[nH]1)C(F)(F)F
InChI Key: InChIKey=JNDDJNAYNOSVPP-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metallo-beta-lactamase type 2 (Serratia marcescens) | BDBM262887 (4'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.456 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase VIM-1 (Klebsiella pneumoniae) | BDBM262887 (4'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.15 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase NDM-1 (Klebsiella pneumoniae) | BDBM262887 (4'-(4-hydroxypiperidin-1-yl)-2- (1H-tetrazol-5-yl)...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.229 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ... | US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K | |||||||||||
More data for this Ligand-Target Pair |