BDBM262979 3-((1r,4r)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tetrazol-5-yl)-6-(trifluoromethyl)benzenesulfonamide::US9708336, 832

SMILES: NS(=O)(=O)c1c(ccc([C@H]2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F

InChI Key:

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262979   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metallo-beta-lactamase type 2 (Serratia marcescens)	BDBM262979 (3-((1r,4r)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tet...) Show SMILES NS(=O)(=O)c1c(ccc([C@H]2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F |r,wD:9.8,(5.6,7.15,;4.27,7.92,;5.04,9.26,;4.67,6.43,;2.94,7.15,;2.98,5.58,;1.6,4.84,;.27,5.61,;.27,7.15,;-1.22,7.55,;-2.7,7.13,;-4.19,7.55,;-4.96,6.22,;-3.48,6.64,;-1.99,6.22,;-4.96,4.68,;-6.29,3.91,;-6.29,2.37,;-4.96,1.6,;-3.63,2.37,;-3.63,3.91,;1.6,7.92,;1.6,9.46,;.36,10.37,;.83,11.83,;2.37,11.83,;2.85,10.37,;4.32,4.81,;5.65,4.04,;3.55,3.48,;5.46,5.84,)| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair
Beta-lactamase VIM-1 (Klebsiella pneumoniae)	BDBM262979 (3-((1r,4r)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tet...) Show SMILES NS(=O)(=O)c1c(ccc([C@H]2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F |r,wD:9.8,(5.6,7.15,;4.27,7.92,;5.04,9.26,;4.67,6.43,;2.94,7.15,;2.98,5.58,;1.6,4.84,;.27,5.61,;.27,7.15,;-1.22,7.55,;-2.7,7.13,;-4.19,7.55,;-4.96,6.22,;-3.48,6.64,;-1.99,6.22,;-4.96,4.68,;-6.29,3.91,;-6.29,2.37,;-4.96,1.6,;-3.63,2.37,;-3.63,3.91,;1.6,7.92,;1.6,9.46,;.36,10.37,;.83,11.83,;2.37,11.83,;2.85,10.37,;4.32,4.81,;5.65,4.04,;3.55,3.48,;5.46,5.84,)| Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.212	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair
Beta-lactamase NDM-1 (Klebsiella pneumoniae)	BDBM262979 (3-((1r,4r)-4-(piperidin-4-yl)cyclohexyl)-2-(1H-tet...) Show SMILES NS(=O)(=O)c1c(ccc([C@H]2CCC(CC2)C2CCNCC2)c1-c1nnn[nH]1)C(F)(F)F |r,wD:9.8,(5.6,7.15,;4.27,7.92,;5.04,9.26,;4.67,6.43,;2.94,7.15,;2.98,5.58,;1.6,4.84,;.27,5.61,;.27,7.15,;-1.22,7.55,;-2.7,7.13,;-4.19,7.55,;-4.96,6.22,;-3.48,6.64,;-1.99,6.22,;-4.96,4.68,;-6.29,3.91,;-6.29,2.37,;-4.96,1.6,;-3.63,2.37,;-3.63,3.91,;1.6,7.92,;1.6,9.46,;.36,10.37,;.83,11.83,;2.37,11.83,;2.85,10.37,;4.32,4.81,;5.65,4.04,;3.55,3.48,;5.46,5.84,)| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.501	n/a	n/a	n/a	n/a	7.0	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...				US Patent US9708336 (2017) BindingDB Entry DOI: 10.7270/Q2FN186K
					More data for this Ligand-Target Pair