BDBM263357 US9546162, 15

SMILES: COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1

InChI Key: InChIKey=VKYPKDVCXGMTIF-UHFFFAOYSA-N

Data: 4 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 263357   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM263357 (US9546162, 15) Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1 Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.800	n/a	n/a	n/a	1	n/a	n/a	7.4	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...				US Patent US9546162 (2017) BindingDB Entry DOI: 10.7270/Q2P55QHV
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM263357 (US9546162, 15) Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1 Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	3	n/a	n/a	n/a	11	n/a	n/a	7.4	n/a
ALLERGAN, INC. US Patent					Assay Description HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom o...				US Patent US9546162 (2017) BindingDB Entry DOI: 10.7270/Q2P55QHV
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP2 subtype (Homo sapiens (Human))	BDBM263357 (US9546162, 15) Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1 Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	259	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
ALLERGAN, INC. US Patent					Assay Description Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...				US Patent US9546162 (2017) BindingDB Entry DOI: 10.7270/Q2P55QHV
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM263357 (US9546162, 15) Show SMILES COc1cccc(Cn2ccc3cccc(CCc4ccc(cc4)C(O)=O)c23)c1 Show InChI InChI=1S/C25H23NO3/c1-29-23-7-2-4-19(16-23)17-26-15-14-21-6-3-5-20(24(21)26)11-8-18-9-12-22(13-10-18)25(27)28/h2-7,9-10,12-16H,8,11,17H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.68E+3	n/a	n/a	n/a	1.62E+3	n/a	n/a	7.4	n/a
ALLERGAN, INC. US Patent					Assay Description Cells were seeded at a density of 5×104 cells per well in Biocoat® Poly-D-lysine-coated black-wall, clear-bottom 96-well plates (Becton-Dickinson) an...				US Patent US9546162 (2017) BindingDB Entry DOI: 10.7270/Q2P55QHV
					More data for this Ligand-Target Pair