BDBM2634 3-(1,2-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolylmaleimide deriv. 56

SMILES: Cc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C

InChI Key: InChIKey=YJRJNBLRNPBJDL-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2634   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM2634 (3-(1,2-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...) Show SMILES Cc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C |t:3| Show InChI InChI=1S/C23H19N3O2/c1-13-19(15-9-5-7-11-18(15)26(13)3)21-20(22(27)24-23(21)28)16-12-25(2)17-10-6-4-8-14(16)17/h4-12H,1-3H3,(H,24,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Roche Products Limited					Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair
Protein Kinase C (Rattus norvegicus (rat))	BDBM2634 (3-(1,2-dimethyl-1H-indol-3-yl)-4-(1-methyl-1H-indo...) Show SMILES Cc1c(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc2n1C |t:3| Show InChI InChI=1S/C23H19N3O2/c1-13-19(15-9-5-7-11-18(15)26(13)3)21-20(22(27)24-23(21)28)16-12-25(2)17-10-6-4-8-14(16)17/h4-12H,1-3H3,(H,24,27,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a	n/a
Roche Products Limited					Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair