BDBM263547 2-{5-amino-1-[4-(2,3-difluoro- phenoxy)-2-methyl-phenyl]-1h- pyrazole-4-carbonyl}-1h-indole- 5-carboxylic acid (2-methoxy- ethyl)-amide::US9556150, i-35

SMILES: COCCNC(=O)c1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc(Oc2cccc(F)c2F)cc1C

InChI Key: InChIKey=FAIWGSNGZQGHPB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 263547   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM263547 (2-{5-amino-1-[4-(2,3-difluoro- phenoxy)-2-methyl-p...) Show SMILES COCCNC(=O)c1ccc2[nH]c(cc2c1)C(=O)c1cnn(c1N)-c1ccc(Oc2cccc(F)c2F)cc1C Show InChI InChI=1S/C29H25F2N5O4/c1-16-12-19(40-25-5-3-4-21(30)26(25)31)7-9-24(16)36-28(32)20(15-34-36)27(37)23-14-18-13-17(6-8-22(18)35-23)29(38)33-10-11-39-2/h3-9,12-15,35H,10-11,32H2,1-2H3,(H,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.15	n/a
Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co. US Patent					Assay Description This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluorescenc...				US Patent US9556150 (2017) BindingDB Entry DOI: 10.7270/Q2571F1S
					More data for this Ligand-Target Pair