BDBM263563 2-(4-{5-amino-4-[5-(piperazine- 1-carbonyl)-1h-indole-2- carbonyl]-pyrazol-1-yl}-3- chloro-phenoxy)-n,n-dimethyl- benzamide acetic acid salt::US9556150, i-51
SMILES: CN(C)C(=O)c1ccccc1Oc1ccc(c(Cl)c1)-n1ncc(C(=O)c2cc3cc(ccc3[nH]2)C(=O)N2CCNCC2)c1N
InChI Key: InChIKey=UHSMGRRCMKVAFZ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM263563 (2-(4-{5-amino-4-[5-(piperazine- 1-carbonyl)-1h-ind...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.15 | n/a |
Hoffmann-La Roche Inc.; Chugai Pharmaceutical Co. US Patent | Assay Description This BTK competition assay measures compound potency (IC50) for the inactivated state of Bruton's Tyrosine Kinase using FRET (Förster/Fluorescenc... | US Patent US9556150 (2017) BindingDB Entry DOI: 10.7270/Q2571F1S | |||||||||||
More data for this Ligand-Target Pair |