BDBM26375 4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}pyrimidin-5-yl)-1-N-[3-(trifluoromethyl)benzene]benzene-1,3-dicarboxamide::Aminopyrimidine amide, 13e

SMILES: Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1

InChI Key: InChIKey=XTXBDMYKIBMUHQ-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM26375 (4-methyl-3-N-(2-{[2-(morpholin-4-yl)ethyl]amino}py...) Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(NCCN2CCOCC2)nc1 Show InChI InChI=1S/C26H27F3N6O3/c1-17-5-6-20(33-23(36)18-3-2-4-19(13-18)26(27,28)29)14-22(17)24(37)34-21-15-31-25(32-16-21)30-7-8-35-9-11-38-12-10-35/h2-6,13-16H,7-12H2,1H3,(H,33,36)(H,34,37)(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 51: 1681-94 (2008) Article DOI: 10.1021/jm7010996 BindingDB Entry DOI: 10.7270/Q2Q81BCB
					More data for this Ligand-Target Pair