BDBM26391 5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole::JNJ 7777120 analogue, 4
SMILES: Clc1ccc2[nH]c(cc2c1)C(=O)N1CCNCC1
InChI Key: InChIKey=RNGVSSIIHLHHSN-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Rattus norvegicus (rat)) | BDBM26391 (5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 4 | -11.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Abbott Laboratories | Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac... | J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM26391 (5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim RCV GmbH& Co KG Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK cells | Eur J Med Chem 54: 660-8 (2012) Article DOI: 10.1016/j.ejmech.2012.06.016 BindingDB Entry DOI: 10.7270/Q2251K7H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM26391 (5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole | JN...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 26 | -10.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Abbott Laboratories | Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac... | J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5 | |||||||||||
More data for this Ligand-Target Pair |