BDBM263942 2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid::US10173996, Example 12::US9604961, Example 12::US9714230, 12::US9908865, Example 12

SMILES: Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O

InChI Key: InChIKey=LKBZHRSAENXIOI-UHFFFAOYSA-N

Data: 18 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 263942   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM5B (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
jmjd2a (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of KDM4C (unknown origin) preincubated with enzyme				Bioorg Med Chem Lett 28: 1490-1494 (2018) Article DOI: 10.1016/j.bmcl.2018.03.083 BindingDB Entry DOI: 10.7270/Q26Q20W4
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263942 (2-(5-p-tolyl-1H-pyrazol-1- yl)isonicotinic acid | ...) Show SMILES Cc1ccc(cc1)-c1ccnn1-c1cc(ccn1)C(O)=O Show InChI InChI=1S/C16H13N3O2/c1-11-2-4-12(5-3-11)14-7-9-18-19(14)15-10-13(16(20)21)6-8-17-15/h2-10H,1H3,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair