null
SMILES: Cc1ccc(COc2ccnn2-c2cc(ccn2)C(O)=O)c(Cl)c1
InChI Key: InChIKey=BNEDYWDXODJLAY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quantical Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quantical Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quantical Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM... | US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quantical Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM... | US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM... | US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 2B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c... | J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4A (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
The Scripps Research Institute | Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ... | J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM264045 (2-[5-[(2-chloro-4- methylphenyl)methoxy]pyrazol-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | 25 |
Celgene Quantical Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6 | |||||||||||
More data for this Ligand-Target Pair |