null

SMILES: OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1

InChI Key: InChIKey=JFUSDWYLUAUIKN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 264055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4A (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2A was determined in 38-well plate format under the following reaction conditions: 2 nM ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264055 (2-[5-[[4-chloro-3- (cyclopropylmethoxy)phenyl] met...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccc(Cl)c(OCC2CC2)c1 Show InChI InChI=1S/C20H18ClN3O4/c21-16-4-3-14(9-17(16)27-11-13-1-2-13)12-28-19-6-8-23-24(19)18-10-15(20(25)26)5-7-22-18/h3-10,13H,1-2,11-12H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair