BDBM2642 (Phenylindolyl)maleimide deriv. 64::3-(1-methyl-1H-indol-3-yl)-4-(3-methylphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione

SMILES: Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12

InChI Key: InChIKey=LHGRZBUIYQSMLQ-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 7 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2642   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM2642 ((Phenylindolyl)maleimide deriv. 64 | 3-(1-methyl-1...) Show SMILES Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12 |t:8| Show InChI InChI=1S/C20H16N2O2/c1-12-6-5-7-13(10-12)17-18(20(24)21-19(17)23)15-11-22(2)16-9-4-3-8-14(15)16/h3-11H,1-2H3,(H,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Roche Products Limited					Assay Description The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair
Protein Kinase C (Rattus norvegicus (rat))	BDBM2642 ((Phenylindolyl)maleimide deriv. 64 | 3-(1-methyl-1...) Show SMILES Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(C)c2ccccc12 |t:8| Show InChI InChI=1S/C20H16N2O2/c1-12-6-5-7-13(10-12)17-18(20(24)21-19(17)23)15-11-22(2)16-9-4-3-8-14(15)16/h3-11H,1-2H3,(H,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Products Limited					Assay Description The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...				J Med Chem 35: 177-84 (1992) Article DOI: 10.1021/jm00079a024 BindingDB Entry DOI: 10.7270/Q2K64G8V
					More data for this Ligand-Target Pair