BDBM264260 6-(2,6-Dichlorophenyl)-8-(3-hydroxyprop-1-yn-1-yl)-2-((3-methyl-4-(piperazin-1-yl)phenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one::US9714244, 14

SMILES: Cc1cc(Nc2ncc3c(n2)c(cn(-c2c(Cl)cccc2Cl)c3=O)C#CCO)ccc1N1CCNCC1

InChI Key: InChIKey=LGFRDPWFQMRGBK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Wee1-like protein kinase (Homo sapiens (Human))	BDBM264260 (6-(2,6-Dichlorophenyl)-8-(3-hydroxyprop-1-yn-1-yl)...) Show SMILES Cc1cc(Nc2ncc3c(n2)c(cn(-c2c(Cl)cccc2Cl)c3=O)C#CCO)ccc1N1CCNCC1 |(-4,4.62,;-4,3.08,;-2.67,2.31,;-2.67,.77,;-1.33,,;,.77,;,2.31,;1.33,3.08,;2.67,2.31,;2.67,.77,;1.33,,;4,,;5.33,.77,;5.33,2.31,;6.67,3.08,;6.67,4.62,;5.33,5.39,;8,5.39,;9.34,4.62,;9.34,3.08,;8,2.31,;8,.77,;4,3.08,;4,4.62,;4,-1.54,;4,-3.08,;4,-4.62,;2.67,-5.39,;-4,,;-5.33,.77,;-5.33,2.31,;-6.67,3.08,;-8,2.31,;-9.34,3.08,;-9.34,4.62,;-8,5.39,;-6.67,4.62,)| Show InChI InChI=1S/C27H24Cl2N6O2/c1-17-14-19(7-8-23(17)34-11-9-30-10-12-34)32-27-31-15-20-24(33-27)18(4-3-13-36)16-35(26(20)37)25-21(28)5-2-6-22(25)29/h2,5-8,14-16,30,36H,9-13H2,1H3,(H,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
ALMAC DISCOVERY LIMITED US Patent					Assay Description In the measurement of Wee-1 activity, a commercial peptide Poly(Lys Tyr(4:1)) hydrobromide was purchased from Sigma Aldrich and used as the substrate...				US Patent US9714244 (2017) BindingDB Entry DOI: 10.7270/Q2GH9KZ4
					More data for this Ligand-Target Pair