BDBM264273 2-((3-Chloro-4-(piperazin-1-yl)phenyl)amino)-6-(2,6-dichlorophenyl)pyrido[4,3-d]pyrimidin-5(6H)-one::US9714244, 27

SMILES: Clc1cccc(Cl)c1-n1ccc2nc(Nc3ccc(N4CCNCC4)c(Cl)c3)ncc2c1=O

InChI Key: InChIKey=BJRMBSFYGNNIOW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 264273   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM264273 (2-((3-Chloro-4-(piperazin-1-yl)phenyl)amino)-6-(2,...) Show SMILES Clc1cccc(Cl)c1-n1ccc2nc(Nc3ccc(N4CCNCC4)c(Cl)c3)ncc2c1=O |(5.33,2.69,;6.67,1.92,;8,2.7,;9.34,1.92,;9.34,.38,;8,-.39,;8,-1.93,;6.67,.38,;5.33,-.39,;5.33,-1.93,;4,-2.7,;2.67,-1.93,;1.33,-2.7,;,-1.93,;-1.33,-2.7,;-2.67,-1.93,;-4,-2.7,;-5.33,-1.93,;-5.33,-.39,;-6.67,.38,;-8,-.39,;-9.34,.38,;-9.34,1.92,;-8,2.69,;-6.67,1.92,;-4,.38,;-4,1.92,;-2.67,-.39,;,-.39,;1.33,.39,;2.67,-.39,;4,.38,;4,1.92,)| Show InChI InChI=1S/C23H19Cl3N6O/c24-16-2-1-3-17(25)21(16)32-9-6-19-15(22(32)33)13-28-23(30-19)29-14-4-5-20(18(26)12-14)31-10-7-27-8-11-31/h1-6,9,12-13,27H,7-8,10-11H2,(H,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
ALMAC DISCOVERY LIMITED US Patent					Assay Description In the measurement of Wee-1 activity, a commercial peptide Poly(Lys Tyr(4:1)) hydrobromide was purchased from Sigma Aldrich and used as the substrate...				US Patent US9714244 (2017) BindingDB Entry DOI: 10.7270/Q2GH9KZ4
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