BDBM26498 N-(2-methyl-5-{[6-(2-methylphenyl)pyrimidin-4-yl]amino}phenyl)methanesulfonamide::aminopyrimidine, 18

SMILES: Cc1ccc(Nc2cc(ncn2)-c2ccccc2C)cc1NS(C)(=O)=O

InChI Key: InChIKey=VHVHHHVCWYYSGD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM26498 (N-(2-methyl-5-{[6-(2-methylphenyl)pyrimidin-4-yl]a...) Show SMILES Cc1ccc(Nc2cc(ncn2)-c2ccccc2C)cc1NS(C)(=O)=O Show InChI InChI=1S/C19H20N4O2S/c1-13-6-4-5-7-16(13)18-11-19(21-12-20-18)22-15-9-8-14(2)17(10-15)23-26(3,24)25/h4-12,23H,1-3H3,(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.19E+5	n/a	n/a	n/a	n/a	4.5	22
Merck Research Laboratories					Assay Description The assay was performed using a 96-well format on a HPLC equipped with four 96-well plate holders. After the reaction was terminated, the solution wa...				Bioorg Med Chem Lett 19: 17-20 (2009) Article DOI: 10.1016/j.bmcl.2008.11.027 BindingDB Entry DOI: 10.7270/Q22J696F
					More data for this Ligand-Target Pair