BindingDB PrimarySearch

BDBM26524 (1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)methoxy]phenyl}methyl)-2-N-hydroxycyclopropane-1,2-dicarboxamide::hydroxamate-cyclopropyl compound, 1

SMILES: NC(=O)[C@@]1(Cc2ccc(OCc3cc(nc4ccccc34)-c3ccccc3)c(F)c2)C[C@@H]1C(=O)NO

InChI Key: InChIKey=ZVRPHGZPZLMEPV-PIKZIKFNSA-N

Data: 8 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 26524
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Disintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q] (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.140	-13.3	n/a	n/a	n/a	n/a	n/a	7.3	22
Schering-Plough Research Institute					Assay Description Enzyme activity was determined by a kinetic assay measuring the rate of increase in fluorescent intensity generated by the cleavage of an internally ...				Bioorg Med Chem Lett 19: 54-7 (2009) Article DOI: 10.1016/j.bmcl.2008.11.034 BindingDB Entry DOI: 10.7270/Q2JH3JH7
Schering-Plough Research Institute					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of human recombinant TACE				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	<1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Matrilysin (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.28E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2.27E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP2				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	4.07E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 10 (Homo sapiens (Human))	BDBM26524 ((1R,2S)-1-({3-fluoro-4-[(2-phenylquinolin-4-yl)met...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of ADAM10				Bioorg Med Chem Lett 18: 5809-14 (2009) Article DOI: 10.1016/j.bmcl.2008.09.045 BindingDB Entry DOI: 10.7270/Q2N29WZX
Schering Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair