BDBM26552 4-(but-2-yn-1-yloxy)-N-methyl-N-[(2S)-2-sulfanylpropyl]benzene-1-sulfonamide::butynyloxy containing compound, 3
SMILES: CC#CCOc1ccc(cc1)S(=O)(=O)N(C)C[C@H](C)S
InChI Key: InChIKey=VRZXDGCRBIXJPJ-LBPRGKRZSA-N
Data: 1 KI
PDB links: 3 PDB IDs contain this monomer as substructures. 3 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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TNF-alpha-Converting Enzyme (Homo sapiens (Human)) | BDBM26552 (4-(but-2-yn-1-yloxy)-N-methyl-N-[(2S)-2-sulfanylpr...) | PDB MMDB B.MOAD GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | 27 | -10.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Vertex Pharmaceuticals | Assay Description The compounds were tested for TACE inhibition using fluorescence resonance energy transfer (FRET) assay. TACE catalyzed cleavage of the substrate pep... | Bioorg Med Chem Lett 17: 2250-3 (2007) Article DOI: 10.1016/j.bmcl.2007.01.064 BindingDB Entry DOI: 10.7270/Q2DV1H67 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) |