BDBM26610 2-methyl-5-{[(oxolan-2-ylmethyl)sulfanyl]methyl}furan-3-carboxylic acid::furan carboxylic acid analogue, 35
SMILES: Cc1oc(CSCC2CCCO2)cc1C(O)=O
InChI Key: InChIKey=GBNFJRLLOAGPHB-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Apurinic-apyrimidinic endonuclease 1 (APE-1) (Homo sapiens (Human)) | BDBM26610 (2-methyl-5-{[(oxolan-2-ylmethyl)sulfanyl]methyl}fu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Southern California | Assay Description To determine the extent of abasic residue cleavage by APE1, recombinant APE1 was preincubated with the potential inhibitors in reaction buffer. Then,... | J Med Chem 52: 20-32 (2009) Article DOI: 10.1021/jm800739m BindingDB Entry DOI: 10.7270/Q21J9822 | |||||||||||
More data for this Ligand-Target Pair |