BDBM26668 CHEMBL494360::N-cyclohexyl-3-[3-(trifluoromethyl)phenyl]-[1,2,4]triazolo[3,4-a]pyridin-6-amine::triazolopyridazine compound, 1
SMILES: FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCCCC3)nn12
InChI Key: InChIKey=XYYDXQCAYXOGQT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26668 (CHEMBL494360 | N-cyclohexyl-3-[3-(trifluoromethyl)...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet... | Bioorg Med Chem Lett 19: 3019-22 (2009) Article DOI: 10.1016/j.bmcl.2009.04.061 BindingDB Entry DOI: 10.7270/Q21J99PJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26668 (CHEMBL494360 | N-cyclohexyl-3-[3-(trifluoromethyl)...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 11 | -11.0 | n/a | n/a | n/a | n/a | n/a | 7.6 | 30 |
Vertex | Assay Description A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate. | J Med Chem 51: 1972-5 (2008) Article DOI: 10.1021/jm701248t BindingDB Entry DOI: 10.7270/Q2HM56RQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |