BDBM26670 2,3-diphenyl-1H-indole-7-carboxylic acid::cid_5003498::diphenylindole carboxylic acid, 3
SMILES: OC(=O)c1cccc2c(c([nH]c12)-c1ccccc1)-c1ccccc1
InChI Key: InChIKey=OLUDUXWVPIEHDA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | 550 | -8.68 | n/a | n/a | n/a | n/a | n/a | 7.6 | 30 |
Vertex | Assay Description A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptor substrate. | J Med Chem 51: 1972-5 (2008) Article DOI: 10.1021/jm701248t BindingDB Entry DOI: 10.7270/Q2HM56RQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corp. Curated by ChEMBL | Assay Description Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo... | J Med Chem 55: 2641-8 (2012) Article DOI: 10.1021/jm2014698 BindingDB Entry DOI: 10.7270/Q2Q2418B | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
streptokinase A precursor (Streptococcus pyogenes M1 GAS) | BDBM26670 (2,3-diphenyl-1H-indole-7-carboxylic acid | cid_500...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem | PCBioAssay | n/a | n/a | n/a | n/a | 1.56E+4 | n/a | n/a | n/a | n/a |
Broad Institute Curated by PubChem BioAssay | Assay Description Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2736PBV | |||||||||||
More data for this Ligand-Target Pair |