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BDBM26697 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione::CHEMBL468280::Isoxazoloquinolinedione, 1

SMILES: CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12

InChI Key: InChIKey=GOKWYLQQNCJARE-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26697   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM26697
PNG
(7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
21.8 -10.3n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.079
BindingDB Entry DOI: 10.7270/Q2833QBF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM26697
PNG
(7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
22n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM26697
PNG
(7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...)
Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12
Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
174 -9.12n/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...


Bioorg Med Chem Lett 18: 5206-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.079
BindingDB Entry DOI: 10.7270/Q2833QBF
More data for this
Ligand-Target Pair