BDBM26697 7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,3-c][1,2]oxazole-3,4-dione::CHEMBL468280::Isoxazoloquinolinedione, 1

SMILES: CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12

InChI Key: InChIKey=GOKWYLQQNCJARE-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26697   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26697 (7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...) Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12 Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	21.8	-10.3	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...				Bioorg Med Chem Lett 18: 5206-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.079 BindingDB Entry DOI: 10.7270/Q2833QBF
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26697 (7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...) Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12 Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...				Bioorg Med Chem Lett 19: 3019-22 (2009) Article DOI: 10.1016/j.bmcl.2009.04.061 BindingDB Entry DOI: 10.7270/Q21J99PJ
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM26697 (7-chloro-9-ethyl-6-fluoro-1H,3H,4H,9H-quinolino[2,...) Show SMILES CCn1c2noc(=O)c2c(O)c2cc(F)c(Cl)cc12 Show InChI InChI=1S/C12H8ClFN2O3/c1-2-16-8-4-6(13)7(14)3-5(8)10(17)9-11(16)15-19-12(9)18/h3-4,17H,2H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	174	-9.12	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm...				Bioorg Med Chem Lett 18: 5206-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.079 BindingDB Entry DOI: 10.7270/Q2833QBF
					More data for this Ligand-Target Pair