null
SMILES: CCn1c2n(CCO)oc(=O)c2c(=O)c2cc(F)c(Cl)cc12
InChI Key: InChIKey=LGMKUVDUTQHORU-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM26705 (7-chloro-9-ethyl-6-fluoro-1-(2-hydroxyethyl)-1H,3H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.16E+3 | -8.01 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm... | Bioorg Med Chem Lett 18: 5206-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.079 BindingDB Entry DOI: 10.7270/Q2833QBF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM26705 (7-chloro-9-ethyl-6-fluoro-1-(2-hydroxyethyl)-1H,3H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | >1.42E+3 | >-7.89 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description Assays were conducted in 384-well v-bottom polypropylene plates. Test compound was mixed with Pim and biotinylated peptide substrate, followed by imm... | Bioorg Med Chem Lett 18: 5206-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.079 BindingDB Entry DOI: 10.7270/Q2833QBF | |||||||||||
More data for this Ligand-Target Pair |